Hairloss

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Biologic Therapy for Hair Restoration

Biologic therapy is an innovative, non-surgical solution for hair loss that uses regenerative compounds—such as exosomes and extracellular matrix (ECM)—to revitalize the scalp, reactivate dormant follicles, and promote new hair growth.

This treatment is well-suited for patients experiencing various forms of alopecia and thinning hair. When applied properly, it improves scalp health and supports long-term hair density.

Step 1

Ideal Candidates

Best suited for patients who have:

  • Androgenetic alopecia (male or female pattern hair loss)

  • Telogen effluvium or post-COVID hair shedding

  • Age-related thinning or hormonal imbalance

  • Post-transplant recovery (FUE/FUT enhancement)

  • Patients looking for PRP alternatives or combination therapy

Contraindications:

  • Active scalp infections

  • Open wounds or recent trauma to the treatment area

  • Known allergy to exosome formulations or anesthetics

  • Severe autoimmune scalp conditions (case-by-case basis)

Step 2

Preparing for the Procedure

Biologic Used:

  • Type: Exosomes from dermal papillary–differentiated stem cells

  • Volume per vial: 1.0 mL

  • Storage: –80°C until use; thaw once; do not refreeze

Mechanism of Action:

  • Promotes anagen phase (active growth) entry

  • Improves blood flow via VEGF signaling

  • Reduces inflammation by suppressing IL-6, TNF-α

  • Supports extracellular matrix restoration

  • Maintains follicular stem cell health (LGR5⁺, K15⁺)

Step 3

Injection Techniques

Delivery Options:

  • Intradermal injection (manual or injector-assisted: U225, EZ Injector)

  • Microneedling (depth: 0.5–1.5 mm)

  • Combined approach for maximum diffusion and follicle stimulation

Dosage per Session:

  • Mild–moderate thinning: 1.0 mL

  • Widespread or advanced loss: 1.5–2.0 mL

  • Use a 1 cm injection grid or even microneedling coverage

Treatment Frequency:

  • Initial series: 3–4 sessions, spaced 2–4 weeks apart

  • Maintenance: Optional follow-ups every 3–6 months based on results

Step 4

Aftercare & Monitoring

Immediately After:

  • Do not wash hair or apply products for 12–18 hours

  • Avoid direct sun, sweating, or scalp stimulation for 24–48 hours

  • Resume growth topicals like minoxidil after 72 hours, if applicable

What to Expect:

  • Mild redness, tingling, or pinpoint bleeding is normal

  • Report any excessive swelling or prolonged discomfort

Step 5

Safety Protocols

During & Post-Treatment:

  • Clean treated areas with sterile gauze

  • Document all observed responses

  • Watch for adverse reactions (rare) like hypersensitivity

Emergency Preparedness:

  • Have epinephrine and antihistamines available

  • Ensure team is trained in first-response care

Step 6

Ongoing Care

First Follow-Up:

  • Review results at each visit (every 3–4 weeks initially)

Evaluate for:

  • Hair density improvement

  • Reduced shedding

  • Scalp health and inflammation

Optional Add-ons:

  • Topicals: Exosome serum, GHK-Cu, PTD-DBM, minoxidil

  • Supplements: Biotin, collagen, Nutrafol®, Viviscal®

  • Devices: LLLT (low-level light therapy) 3x/week

  • Lifestyle: Protein-rich diet, reduced stress, hormone balance

Step 7

Documentation & Tracking

Procedure Records Should Include:

  • Product used (lot number, source)

  • Volume administered

  • Delivery method (injection/microneedling)

  • Injection pattern or areas treated

Tracking Results:

  • Patient feedback and outcomes

  • Progress over time

  • Any deviations or reactions

Summary

Biologic therapy offers a cutting-edge, natural method for stimulating hair growth without surgery. With a structured treatment plan, trained providers can deliver safe and reliable outcomes. This protocol helps restore confidence and improve scalp health while offering patients a minimally invasive alternative to traditional hair restoration methods.

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