Knee Injury

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Regenerative Therapies for Knee Injury

Biologic therapies offer a non-surgical option for patients suffering from knee pain or soft tissue injury. By targeting inflammation and encouraging tissue repair, these treatments help restore joint function and improve mobility.

This protocol outlines how to safely administer intra-articular (joint) and intramuscular (IM) biologics to treat common knee conditions such as osteoarthritis, ligament damage, and meniscal tears.

Step 1

Ideal Candidates

Best suited for patients who have:

  • Mild to moderate knee osteoarthritis

  • Meniscal damage, ligament sprains (ACL, MCL), or chronic tendinopathy

  • Active individuals or athletes looking to speed up recovery or avoid surgery

Contraindications:

  • Infections near the knee or systemic inflammation

  • Severe degenerative damage requiring joint replacement

  • Uncontrolled conditions like diabetes, clotting disorders, or autoimmune disease

  • Allergy risk to injectables, stem cell products, or anesthetics

Step 2

Preparing for the Procedure

Clinic Setup

  • Disinfect surfaces and instruments to maintain a sterile environment

  • Ensure all materials are within expiration and stored properly

Essential Equipment:

  • Biologic vials (stem cells, exosomes)

  • 3–5 mL sterile syringes

  • Topical antiseptics (e.g., alcohol, chlorhexidine)

  • Ultrasound for guided injection

  • Local anesthetic if needed

Patient Prep

  • Informed consent: Clearly explain the procedure, risks, and recovery plan

  • Pain relief options: Offer topical or injectable anesthetic (allow 5–15 mins for effect)

  • Skin prep: Thoroughly clean the knee area to reduce infection risk

Step 3

Injection Techniques

Types of Injection:

  • Intra-Articular: Direct injection into the joint to reduce pain and support cartilage repair

  • Intramuscular: For tendon or muscle injuries surrounding the knee (e.g., quads, patella)

Step-by-Step Protocol:

  • Use ultrasound to identify the target area

  • Draw 1–3 mL of biologic solution into a sterile syringe

  • For joint injections, use a medial or lateral approach under guidance

  • For muscular injections, target inflamed areas like the rectus femoris or lower quadriceps

  • Apply light pressure after the injection and monitor for any discomfort

Step 4

Aftercare & Monitoring

Immediately After:

  • Limit strenuous movement or heavy impact for 1–2 days

  • Mild soreness or swelling is common and typically resolves quickly

  • Pain Management:

  • Use acetaminophen for discomfort

  • Avoid NSAIDs to protect the healing phase and maximize regenerative impact

Step 5

Safety Protocols

First Visit:

  • Reassess in 2–4 weeks

  • Evaluate pain levels, joint mobility, and recovery progress

  • Decide if more sessions are needed based on outcomes

Long-Term Care:

  • Continue monitoring every few months

  • Additional injections can be spaced 4–6 weeks apart, depending on response

  • Adjust treatment as needed based on clinical evaluation

Step 6

Ongoing Care

During the Procedure:

  • Observe the patient for 10–15 minutes after the injection

  • Watch for allergic responses or unexpected discomfort

Emergency Readiness:

  • Keep epinephrine and antihistamines available

  • Ensure the care team is trained for emergency response, even though incidents are rare

Preventing Infection:

  • Use aseptic technique at every stage

  • Do not reuse any equipment or open materials outside of a sterile zone

Step 7

Documentation & Tracking

Keep detailed notes in the patient’s medical record, including:

  • Product type, dose, and batch number

  • Injection site and approach used

  • Patient response and aftercare instructions

  • Follow-up results and any adjustments to care plan

Summary

Biologic treatments for knee pain provide a powerful, non-invasive option for restoring mobility and improving quality of life. This step-by-step protocol helps clinicians deliver consistent, safe, and patient-centered care—especially for those looking to avoid surgery or extend the benefits of post-op recovery.

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